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Pheochromocytoma, Paragangliomas : VHL Alliance

28/9/2020 · VHL is associated with a usually benign type of tumor occurring in the adrenal glands, called a pheochromocytoma (pheo). Pheos occur more frequently in some families than others. They are rarely malignant (less than 7% of the time) among people

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The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1 – PubMed

Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and degrades hypoxia

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Pheochromocytoma in Von Hippel-Lindau Disease | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic

1/3/2003 · The VHL gene is a tumor suppressor gene and is involved in blood vessel formation by regulation of the activity of hypoxia-inducible factor (HIF)-1α. On the basis of its clinical expression, VHL disease has been divided into four subtypes with a

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The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Then, we will dissect the underlying mechanisms in VHL/HIF axis-driven PPGL pathogenesis, with special attention paid to the interplay between the VHL/HIF axis and cancer cell metabolism. Finally, we will summarize the currently available

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Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression

Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under

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National Institutes of Health

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Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression, Carcinogenesis | 10.1093/carcin/bgl205 | DeepDyve

27/10/2006 · Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under

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Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway – ScienceDirect

1/11/2009 · In PC12 rat pheochromocytoma cells vitexin, apigenin-8-C-β-D-glucopyranoside, inhibited HIF-1α and reduced mRNA level of hypoxia-inducible genes i.e., VEGF, smad3, aldolase A, enolase 1, and collagen type III .

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Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration – ScienceDirect

1/10/2015 · Apigenin is a common dietary plant flavonoid widely distributed in vegetables and fruits. It exhibits chemopreventive activity against various cancer cells. In this study, we demonstrated that apigenin directly blocked heat shock protein 90

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Von Hippel-Lindau tumor suppressor: Not only HIF's executioner | Request PDF

Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex

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Prolyl hydroxylase domain enzymes and their role in cell signaling and cancer metabolism – ScienceDirect

1/11/2016 · Hypoxia or inhibition of PHD3 or VHL lead to an aberrant expression level of erythropoietin receptor and erythropoietin-dependent downstream signaling. Moreover, the accumulation of truncated erythropoietin receptor at the plasma membrane,

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Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function | Request PDF

of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal TBB (4,5,6,7-tetrabromotriazole) and apigenin, as well as

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IJMS | Free Full-Text | Hypoxia and Oxygen-Sensing Signaling in Gene Regulation and Cancer Progression – MDPI

VHL syndrome is an autosomal-dominant, hereditary neoplastic disease associated with clear cell renal cell carcinoma (ccRCC), central nervous system hemangioblastomas, and pheochromocytoma []. The disease is caused by germline mutations in VHL ,

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(PDF) Phosphorylation of the von Hippel–Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1α

The VHL protein can be phosphorylated by protein kinase CK2 at serines 33, 38 and 43. However, the role of VHL phosphorylation in the context of p53 and HIF-1alpha regulation remained so far

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(PDF) Reactive Oxygen Species: A Promising Therapeutic Target for SDHx-Mutated Pheochromocytoma and Paraganglioma

27/7/2021 · VHL-mutated PHEO/PGL [45], which may play a role in the malignancy rates of patients with these mutations [66]. Thus, enzyme inhibitors may enable overproduction of ROS

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